Table I

Milestones

Authors Citation Submitted Published

Polyhedron-shaped bodies are associated with disease of silkworms

Memorie dell' I.R. Instituo Lombardo di Scienze, Lettere ed Arti 1856

6:3-387 [Parte quarta: Patologia del baco., pp. 332-336]: Monografia del bombice del gelso (Bombyx mori Linneo). Frammenti anatomici, fisiologici e patologici sul baco da seta 1856

(Bombyx mori Linn). Fratelli Fusi, Pavia, p. 172 Correctly associated polyhedral bodies observed in the 1894

disease, silkworm jaundice, with the disease Discovered that polyhedra are alkali-sensitive Atti e Mem. dell' i.R. Soc. Agr. Gorizia 34:133-136: Il giallume od il mal del grasso del baco da seta. Communicaizone preliminare. Proposed the name polyhedrosis 1906

Biol. Zentr. 26:448-463; 534-544: Über die Ursachen der

Disposition und über Frühsymptome der Raupenkrankheiten. Goldschmidt, R. Culture of insect tissues in vitro: explant of Cecropia moth 1915

spermatozoa Pro. Nat. Acad. Sci. A 1:220-222: Some experiments on spermatogenesis in vitro.

Glaser, R. W. Demonstrated in vitro formation of NPV in harvested blood 1917

cells from infected insects, observed in hanging drops

Psyche. 24:1-7: The growth of insect blood in vitro. Komarek, J., Breindl, V. Proposed that virions are occluded within polyhedra 1924

Z. Angew. Entomol. 10:99-162: Die Wipfel-Krankheit der Nonne und der Erreger derselben. European field introduction of baculovirus for insect control Klock Fortwiss. Cent. 47:241-245: Zur Losung der 1925

Nonnenbekampfungsfrage Auf biologischem Wege.

Cornalia, E.

Fischer, E.

Forstwiss. Zentr. 47:537-538: Einige Bemerkungen über die Nonnenbekämpfung auf biologischen Wege.

Discovery of granulosis virus

Compt. Rend. Acad. Sci. 182:180-182: Sur une nouvelle maladie du noyau ou grasserie* des chenilles de P. brassicae et un nouveau groupe de microorganismes parasites.

First (modern) treatise on diseases of insects

Traité des maladies du ver a soie. G. Doin et Cie, Paris, p. 279

L'Infection chez les insectes. G. Patissier, Trévoux, p. 535

Demonstrated baculovirus infection in cultured insect tissue and the subculture of virus infectivity to healthy cultures

J. Exp. Med. 61:501-513: Cultivation of the virus of grasserie in silkworm tissue cultures.

Demonstrated virions by alkali dissolution of inclusion bodies

Arch Gesell. Virusforschung 1:120-129: Essai d'isolement du virus de la grasserie des vers a soie par l'ultracentrifugation.

North American field introduction of baculovirus for insect control

Sci. Agr. 25:65-80: A disease of the European spruce sawfly, Gilpiniia hercyniae (Htg.), and its place in natural control.

Comprehensive early studies on purification of baculovirus virions, confirmed that virus-like particles were occluded in polyhedra

Z. f. Naturforsch. 2b:122-143: Die Isolierung des Polyeder-Virus und die Natur der Polyeder.

Landmark book and review of pathogens of insects including occluded viruses and their potential for insect control

Principles of Insect Pathology. McGraw-Hill, New York. p. 757

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